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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1946 1
1948 1
1950 5
1951 4
1952 1
1953 4
1954 4
1955 3
1956 3
1957 2
1959 1
1961 1
1962 5
1963 6
1964 8
1965 7
1966 5
1967 8
1968 10
1969 22
1970 4
1971 11
1972 7
1973 14
1974 13
1975 32
1976 42
1977 35
1978 49
1979 49
1980 61
1981 32
1982 55
1983 70
1984 64
1985 84
1986 85
1987 104
1988 119
1989 147
1990 155
1991 168
1992 163
1993 215
1994 224
1995 257
1996 298
1997 343
1998 353
1999 340
2000 408
2001 419
2002 462
2003 468
2004 631
2005 768
2006 858
2007 915
2008 1002
2009 1042
2010 1205
2011 1326
2012 1446
2013 1598
2014 1754
2015 1799
2016 1973
2017 2016
2018 2291
2019 2268
2020 2357
2021 2750
2022 2912
2023 2850
2024 1185

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36,439 results

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Page 1
Predictive reward signal of dopamine neurons.
Schultz W. Schultz W. J Neurophysiol. 1998 Jul;80(1):1-27. doi: 10.1152/jn.1998.80.1.1. J Neurophysiol. 1998. PMID: 9658025 Free article. Review.
The dopamine reward signal is supplemented by activity in neurons in striatum, frontal cortex, and amygdala, which process specific reward information but do not emit a global reward prediction error signal. ...Among the other projection systems, noradrenalin …
The dopamine reward signal is supplemented by activity in neurons in striatum, frontal cortex, and amygdala, which process specific r …
Branched Chain Amino Acids.
Neinast M, Murashige D, Arany Z. Neinast M, et al. Annu Rev Physiol. 2019 Feb 10;81:139-164. doi: 10.1146/annurev-physiol-020518-114455. Epub 2018 Nov 28. Annu Rev Physiol. 2019. PMID: 30485760 Free PMC article. Review.
Decades of studies have elicited a deep understanding of biochemical reactions involved in BCAA catabolism. In addition, BCAAs and various catabolic products act as signaling molecules, activating programs ranging from protein synthesis to insulin secretion. How these proc …
Decades of studies have elicited a deep understanding of biochemical reactions involved in BCAA catabolism. In addition, BCAAs and various c …
The role of mitochondria in aging.
Bratic A, Larsson NG. Bratic A, et al. J Clin Invest. 2013 Mar;123(3):951-7. doi: 10.1172/JCI64125. Epub 2013 Mar 1. J Clin Invest. 2013. PMID: 23454757 Free PMC article. Review.
Recent evidence suggests that increases in aging-associated mtDNA mutations are not caused by damage accumulation, but rather are due to clonal expansion of mtDNA replication errors that occur during development. Here we discuss the caveats of the traditional mitochondrial …
Recent evidence suggests that increases in aging-associated mtDNA mutations are not caused by damage accumulation, but rather are due to clo …
Review: ER stress-induced cell death in osteoarthritic cartilage.
Rellmann Y, Eidhof E, Dreier R. Rellmann Y, et al. Cell Signal. 2021 Feb;78:109880. doi: 10.1016/j.cellsig.2020.109880. Epub 2020 Dec 8. Cell Signal. 2021. PMID: 33307190 Free article. Review.
Various cellular stresses, such as hypoxia, nutrient deprivation, oxidative stress or the accumulation of advanced glycation end products (AGEs) during aging, but also translational errors or mutations in cartilage components or chaperone proteins affect the synthesis and …
Various cellular stresses, such as hypoxia, nutrient deprivation, oxidative stress or the accumulation of advanced glycation end products (A …
Dopamine reward prediction-error signalling: a two-component response.
Schultz W. Schultz W. Nat Rev Neurosci. 2016 Mar;17(3):183-95. doi: 10.1038/nrn.2015.26. Epub 2016 Feb 11. Nat Rev Neurosci. 2016. PMID: 26865020 Free PMC article. Review.
Recent work suggests that the phasic dopamine reward prediction-error response follows a similar sequential pattern. An initial brief, unselective and highly sensitive increase in activity unspecifically detects a wide range of environmental stimuli, then quickly evolves i …
Recent work suggests that the phasic dopamine reward prediction-error response follows a similar sequential pattern. An initial brief …
Innate virus-sensing pathways in B cell systemic autoimmunity.
Vinuesa CG, Grenov A, Kassiotis G. Vinuesa CG, et al. Science. 2023 May 5;380(6644):478-484. doi: 10.1126/science.adg6427. Epub 2023 May 4. Science. 2023. PMID: 37141353 Review.
These two systems are intricately linked, with innate immunity playing an instrumental role in the induction of adaptive antiviral immunity. In this work, we review how inborn errors of innate immunity can instigate B cell autoimmunity. Increased nucleic acid sensing, ofte …
These two systems are intricately linked, with innate immunity playing an instrumental role in the induction of adaptive antiviral immunity. …
Glucocorticoid Resistance.
Nicolaides NC, Charmandari E. Nicolaides NC, et al. Exp Suppl. 2019;111:85-102. doi: 10.1007/978-3-030-25905-1_6. Exp Suppl. 2019. PMID: 31588529 Review.
The ever-increasing application of novel technologies, including the next-generation sequencing, will enhance our knowledge in factors that influence the glucocorticoid signal transduction in a positive or negative fashion....
The ever-increasing application of novel technologies, including the next-generation sequencing, will enhance our knowledge in factors that …
JAKs and STATs from a Clinical Perspective: Loss-of-Function Mutations, Gain-of-Function Mutations, and Their Multidimensional Consequences.
Ott N, Faletti L, Heeg M, Andreani V, Grimbacher B. Ott N, et al. J Clin Immunol. 2023 Aug;43(6):1326-1359. doi: 10.1007/s10875-023-01483-x. Epub 2023 May 4. J Clin Immunol. 2023. PMID: 37140667 Free PMC article. Review.
The JAK/STAT signaling pathway plays a key role in cytokine signaling and is involved in development, immunity, and tumorigenesis for nearly any cell. At first glance, the JAK/STAT signaling pathway appears to be straightforward. However, on closer examinatio …
The JAK/STAT signaling pathway plays a key role in cytokine signaling and is involved in development, immunity, and tumorigene …
Error-proneness as a handicap signal.
De Jaegher K. De Jaegher K. J Theor Biol. 2003 Sep 21;224(2):139-52. doi: 10.1016/s0022-5193(03)00135-8. J Theor Biol. 2003. PMID: 12927522
This paper describes two discrete signalling models in which the error-proneness of signals can serve as a handicap signal. ...The conditions for honesty are that the probability of an error of detection is higher for a high-quality than for a l …
This paper describes two discrete signalling models in which the error-proneness of signals can serve as a handicap …
Updating dopamine reward signals.
Schultz W. Schultz W. Curr Opin Neurobiol. 2013 Apr;23(2):229-38. doi: 10.1016/j.conb.2012.11.012. Epub 2012 Dec 22. Curr Opin Neurobiol. 2013. PMID: 23267662 Free PMC article. Review.
Recent work has advanced our knowledge of phasic dopamine reward prediction error signals. The error signal is bidirectional, reflects well the higher order prediction error described by temporal difference learning models, is compatible with mo …
Recent work has advanced our knowledge of phasic dopamine reward prediction error signals. The error signal is b …
36,439 results
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